No difference in protein expression of Mfn2, OPA1 (mitochondrial fusion), PINK1, and Parkin (mitophagy) or in mRNA expression of PGC1α and TFAM (mitochondrial biogenesis). mRNA expression of Fis1 (mitochondrial fission) and protein expression of LC3BI (autophagy) increased in CC vs. CNC patients (P < 0.05). The gene discussed is TFAM; the disease is Carney complex.