Significant decrease in protein expression of MyHC (P = 0.036), actin, Akt (P = 0.001), FOXO1 (P = 0.011), phosphorylated forms of FOXO3a (P = 0.011), mTOR (P = 0.007), and S6K (P = 0.033) in CC vs. CNC patients. Regulators of muscle contraction, protein synthesis, and protein degradation inhibitors. This evidence concerns the gene FOXO3 and Carney complex.