Significant decrease in myofibers cross‐sectional area in patients with muscle loss ± cachexia (P < 0.05). No difference for patients without muscle loss. Ultrastructure disorganization and autophagosome formation in CC patients. Increased protein and mRNA expression of autophagic–lysosomal (Beclin‐1, LC3B, and p62) and ubiquitin–proteasome (MuRF1 and polyubiquitinylated proteins) systems markers in CC patients (all P < 0.05). This evidence concerns the gene TRIM63 and Cachexia.