A role for DNAM-1-mediated control of herpesvirus infections by NK cells was previously demonstrated for the HCMV-encoded UL141 protein (Hsu et al., 2015; Prod’homme et al., 2010; Tomasec et al., 2005), MCMV m20.1 (Lenac Rovis et al., 2016), and HSV-2-encoded gD protein (Grauwet et al., 2014; De Pelsmaeker et al., 2018). This evidence concerns the gene CD226 and Herpesviridae infectious disease.