Fibroblasts from GA patient 2 (sub-cluster 7), meanwhile, expressed elevated amounts of SPOCK1 (Avg-Log FC: 0.99), CRLF1 (Avg-Log FC: 1.38), and COMP (Avg-Log FC: 1.35), a cartilage protein that is upregulated in matrix-producing fibroblasts after myocardial infarction (Fu et al., 2018). This evidence concerns the gene COMP and myocardial infarction.