Based on the IHC results for these two proteins in duodenum tissue samples of patients with PaC with/without DM (Figure 1), the mean IHC score of duodenal P-gp in the DM group was significantly higher than that in the non-DM group (Table 2; Figure 2A-F), whereas the mean IHC score of duodenal CYP3A4 was not significantly different between the two groups (Table 2; Figure 3A-F). The gene discussed is CYP3A4; the disease is diabetes mellitus.