A recent study showed that the expression of intestinal P-gp was significantly increased with the progression of diabetes in rats (induced by low dose streptozotocin and high-fat diet), resulting in a significant decrease in the intestinal uptake and peroral bioavailability of the P-gp/CYP substrates verapamil and atorvastatin (21). The gene discussed is PGP; the disease is diabetes mellitus.