However, although high ps-Tg values in the postoperative period (>10–30 ng/mL) may be associated with worse survival (11,12), and ps-Tg values greater than 5-10 ng/mL correlate with the increased probability of avid 131I metastatic disease in the postoperative period (16, –18), the ps-Tg value associated with distant metastases at the time of the postoperative evaluation is not defined. The gene discussed is TG; the disease is metastatic neoplasm.