Its main function is to initiate neutrophil extravasation into tissues in acute and chronic inflammatory diseases.(46,47) Soluble E-selectin becomes available in plasma upon apoptosis of activated endothelial cell, correlating with the degree of endothelial activation, and higher plasma levels are associated with sepsis and sepsis severity.(29,48,49) Together, the independent association of RH-PAT with syndecan-1 and sE-selectin levels in our results suggests that glycocalyx integrity and endothelial activation may have a role in vascular reactivity, more specifically with reactive hyperemia. The gene discussed is SDC1; the disease is Sepsis.