Heparanase-1 expression is co-related with sialic acid-binding immunoglobulin-like lectin 7, leukocyte associated immunoglobulin-like receptor 1, phosphoinositide-3-kinase adaptor protein 1 and cathepsin L. The sialic acid-binding immunoglobulin-like lectin 7, leukocyte-associated immunoglobulin-like receptor 1 and phosphoinositide-3-kinase adaptor protein 1 are directed related with immune system evasion during breast cancer progression. The gene discussed is HPSE; the disease is breast cancer.