ERBB2 and triple-negative breast carcinoma: Once bound by sialic acid, SIGLEC7 causes a downstream cascade that prevents degranulation of NK cells.(10) A significant positive correlation between HPSE and SIGLEC7 was observed in luminal A/B, HER2-enriched, and triple-negative breast cancer (y=0.55x-0.24, R2=0.51, p=3.06 x 10-76, n=460; basal subtype, y=0.1191x+0.5550, R2=0.52, p=0.0003; HER2-enriched, y=0.1387x+0.6429, R2=0.6509, p<0.0001; Luminal, y=0.003224x+0.4915, R2 =0.5019, p<0.0001) (Figure 3A).