Such interaction prevents the NK cells from provoking the death of tumor cells through degranulation.(19) Interestingly, an increased expression of SIGLEC7 was observed in macrophages that reside in the tumor microenvironment.(19,20) Sialic acid-binding immunoglobulin-like lectin 7 present on monocytes induce the production of inflammatory factors, such as TNF-α, IL-1α, IL-6, IL-8, MIP-1β.(10) Furthermore, pathogens and tumor cells that overexpress SA and carbohydrate ligands of SIGLEC7 contribute to the inhibition of NK and T cells. This evidence concerns the gene CCL4 and neoplasm.