The effect of priming correlated with the species-specific ability of TRIM5 to restrict the priming virus, as priming with an equal CrFK MOI of a WT capsid-bearing virus that was otherwise identical to HIV-1 CA P90A was significantly less efficient in restricting WT HIV-1 infection of THP1 cells (Figs 6E and S4C). The gene discussed is TRIM5; the disease is HIV-1 infection.