DDEC can be any of the four molecular subtypes of EC [25–27] i.e. POLEmut (with a mutation in the exonuclease domain of polymeras epsilon (POLE) leading to an ultramutated tumor), MMRd (mismatch repair insufficiency, associated with hypermutated EC), p53abn (serous-like and corresponding to tumors with high numbers of somatic copy number alterations in TCGA), and NSMP (no specific molecular phenotype, lacking POLE mutation, MMR deficiency or TP53 mutations). This evidence concerns the gene POLE and neoplasm.