TP53 and neoplasm: DDEC can be any of the four molecular subtypes of EC [25–27] i.e. POLEmut (with a mutation in the exonuclease domain of polymeras epsilon (POLE) leading to an ultramutated tumor), MMRd (mismatch repair insufficiency, associated with hypermutated EC), p53abn (serous-like and corresponding to tumors with high numbers of somatic copy number alterations in TCGA), and NSMP (no specific molecular phenotype, lacking POLE mutation, MMR deficiency or TP53 mutations).