POC1A and Nail dysplasia: As the core component of the centrosome, POC1A is regarded as a factor that regulates the cell cycle; mutation of POC1A can lead to abnormal mitotic mechanics, multipolar spindles and impaired ciliogenesis which can induce short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) [24, 25].