ACE2 and COVID-19: Controversy surrounds the use of nonsteroidal anti-inflammatory drugs (NSAID) in COVID-19 stemming from a correspondence published on March 11, 2020, in the Lancet describing a theoretical risk of worsening infection through increased ACE-2 expression with ibuprofen based on animal studies.93 Initial WHO recommendations were to avoid ibuprofen based on this concern, and on March 19 the US Food and Drug Administration issued a statement suggesting a lack of scientific evidence in connection with NSAIDs and worsening COVID-19 symptoms.