Rates of BRAF p.V600E substitution in preoperative thyroid nodule specimens with malignant/Bethesda VI cytology reported in the literature7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27. This evidence concerns the gene BRAF and thyroid nodule.