In this and other CML cell lines, it has been shown that CK2 co-localizes and interacts with the BCR-ABL fusion protein, an aberrantly activated tyrosine kinase resulting from the chromosomal translocation t(9;22)(q34;q11) and responsible for the onset of this malignancy. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.