NOTCH1 and acute lymphoblastic leukemia: Aberrant activation of the transcription factor c-Myc mediated by Notch1 is a crucial event in T-ALL initiation, and it was found that both CX-4945 and JQ1 impair this axis (the first hampering Notch-1 signalling, the latter reducing c-Myc expression), thereby contributing to reducing c-Myc transcriptional activity [44, 68].