RBFOX3 and Alzheimer disease: Compared with the WT group (9.6% ± 0.2%), 3×Tg-AD mice in the sham and FUS groups showed neuronal compromise, with NeuN-positive areas of 8.2% ± 0.3% (p < 0.001) and 8.2% ± 0.2% (p < 0.001) in the hippocampus respectively (Figure 8B).