Interestingly, six proteins (SYN1, DPYL2, CRYM, PGAM1, UCHL1, TBB2A) were found to be commonly differentially expressed in the sham-treated 3×Tg-AD vs. The WT group and the FUS/MB-treated vs. sham-treated 3×Tg-AD group (Figure 10D). The gene discussed is PGAM1; the disease is Alzheimer disease.