Synaptic protein (SYN1, DPYL2), mitochondrial protein (CRYM), glycolytic protein (PGAM1), microtubule protein (TBB2A), and ubiquitin protein (UCHL1) were downregulated in the hippocampus of sham-treated 3×Tg-AD mice vs. WT mice, but upregulated in the FUS/MB group vs. the sham group. The gene discussed is SYN1; the disease is Alzheimer disease.