Enhanced delivery of anti-amyloid-beta peptide (anti-Aβ) antibodies was found in the FUS/MB-targeted brain regions of two AD mice models (B6C3-Tg and PDAPP, center frequency: 0.69 MHz, peak rarefactional pressure: 0.67-0.8 MPa) 9. The gene discussed is APP; the disease is Alzheimer disease.