MTOR and neoplasm: In vitro, xenograft and/or tail vein injection experiments in mouse models provided evidence that total and membranous SLC14A1 inhibited cell viability, proliferation, migration, invasion, ECAR, tumor growth and metastasis, induced mitochondrial fusion, increased the OCR along with upregulation of proteins related to mitochondrial respiration and downregulated proteins associated with aerobic glycolysis, which may be mediated by downregulation of arginine and phosphorylated/active MTOR and RPS6.