Clinical, in vitro and in vivo evidence strongly suggested that upregulation of HK2 in ovarian cancer was correlated with metastasis and poor survival and mediated migration, invasion and stemness via PTK2/MAPK1/3/MMP9/NANOG/SOX9 signaling cascades in vitro and in a nude mouse model 27. The gene discussed is MAPK1; the disease is ovarian carcinoma.