GSK-3β inhibitor 9ING41 attenuates lung injury progression and pleural fibrosis in a mouse model of Streptococcus pneumoniaee-induced empyema by reducing Tyr-216 phosphorylation of GSK-3β, which results in reduced α-SMA and COLI, and blocked induction of mesothelial mesenchymal transition 121 (Figure 2, Table 4). This evidence concerns the gene GSK3B and empyema.