GSK3B and congenital bilateral aplasia of vas deferens from CFTR mutation: Additionally, celastrol, a natural compound and nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) inhibitor, can mitigate aortic valve fibrosis by upregulating GSK-3β gene expression in cultured porcine aortic valvular interstitial cells (AVICs) and the rabbit calcific aortic valve disease (CAVD) models, as evidenced by attenuated fibrotic marker FN 80.