Hind et al.81 demonstrated that GSK-3β knockout mice markedly triggers the transformation of fibroblasts to myofibroblasts and the accumulation of ECM, leading to a significant increase in fibrosis and scar formation, suggesting that GSK-3β is a vital inhibitor of myocardial fibrosis, especially in the remodeling stage after MI. This evidence concerns the gene GSK3B and Myocardial fibrosis.