Nakayama et al. found that stable expression of EBNA2 and LMP1 downregulated CXCR4 expression 30, and it has been proven that transfection of EBNA2 or LMP1 decreased CXCR4 expression in B cell lymphoma-derived cells 31. Here, CXCR4 is linked to B-cell non-Hodgkin lymphoma.