FOXO1 and neoplasm: After polarization of THP-1 cells into M0 and M2 macrophages (Figure S2C), we performed a migration assay and the result showed that the migrated M2 macrophages were significantly increased when induced with FOXO1(+) tumor cells after 48-h incubation (Figure 3E), whereas the number of migrated M0 macrophages remained unchanged between FOXO1(+) and FOXO1(-) induction (Figure S2D).