Considering the facts that TGFBR1 directly recruits TRAF637 and that TAB2 recruit TAK1 to TRAF6 through direct interaction with both protein 38, we hypothesized that CLU inhibited TGFBR1 to recruit TRAF6/TAB2/TAK1 complex in lung cancer cells, and thereby inhibit the signaling of downstream TAK1-NF-κB signaling pathway. The gene discussed is TGFBR1; the disease is lung cancer.