On the other hand, our inhibitor screening experiment has shown that NF-κB inhibitor BAY001 or TAK1 inhibitor NG25 significantly inhibited colony formation of HOP62-shCLU (Figure 2A), suggesting that CLU inhibited lung cancer cells by negatively regulating TAK1-NF-κB signal axis. The gene discussed is NFKB1; the disease is lung carcinoma.