The ability of DAPK1 inhibition or depletion to prevent the LPS-induced tubular apoptosis under hypoxia in vitro prompted us to dissect whether inhibition or depletion of DAPK1 counteracts septic AKI, the thorny clinical disease characterized by systemic inflammatory response syndrome (SIRS) in conjunction with ischemic/hypoxic tubular damage. This evidence concerns the gene DAPK1 and systemic inflammatory response syndrome.