CASP8 and acute kidney injury: Because DAPK1 inhibitor also blocks the hypoxia-dependent Pellino1 Ser39 phosphorylation, caspase-8 recruitment of TRIF-RIP1 signalosome and tubular apoptosis during LPS stimuli, it is possible that pharmacological deactivation or genetic ablation of DAPK1 protects mice from septic AKI via controlling these events.