As observed in hematoxylin and eosin (H&E) staining, the CLP-treated animals developed kidney disease with characteristic features of acute kidney injury (AKI), including loss of epithelial brush border, tubular epithelial vacuolization and epithelial desquamation, while DAPK1-i administration efficiently alleviated these phenotypes (Figure 6B). The gene discussed is DAPK1; the disease is kidney disorder.