DAPK1 and acute kidney injury: Additional evidence that DAPK1 deactivation protects mice against septic AKI was obtained from the biochemical detection, where the levels of serum creatinine (Scr), blood urea nitrogen (BUN) and lactate from CLP-treated animals with DAPK1-i injection were much less than those from their littermates with PBS injection (Figure 6C-E).