We identified 1179 genes with upregulated expression in HCC tissue samples from the TCGA database (Fig. S7B) and then identified four proteins, IGF2BP1, IGF2BP3, PKM, and ANXA2, with increased expression in HCC tissue that interacted with PTPN13 (Fig. 5C, right panel). This evidence concerns the gene ANXA2 and hepatocellular carcinoma.