In addition, we reintroduced an engineered PTPN13 cDNA that was not sensitive to shRNA #4 into shPTPN13 (shOE) cells to examine whether PTPN13 re-expression could reverse the changes in HCC cell function induced by shPTPN13 (Fig. 4A). This evidence concerns the gene PTPN13 and hepatocellular carcinoma.