To explore whether Gfi1 regulated c-Myc expression in lymphoma cells, we expressed the Dox-inducible Gfi1 in human Burkitt′s lymphoma Ramos cells (Ramos/Gfi1), which carried the characteristic t(8;14) chromosomal translocation that linked c-MYC to the immunoglobulin heavy-chain gene (IgH). The gene discussed is GFI1; the disease is lymphoma.