Ribose-modified BSA is a good model protein for detection of the Anti-AGE-Ab due to high prevalence of modifications (MG-H1, CML, pentosidine) (Supplementary Fig. 4) compared to BSA as a control due to low amount of modification and high structural similarity to native HSA. The gene discussed is ALB; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.