Interestingly, GCKR encodes the glucokinase regulatory protein (GKRP), which is a hepatocyte-specific inhibitor of the glucose-metabolizing enzyme glucokinase (GCK), previously associated with different metabolic traits including T2D, non-alcoholic fatty liver, fasting insulin and total cholesterol levels37. The gene discussed is GCK; the disease is type 2 diabetes mellitus.