KLK3 and pachyonychia congenita: Further, there was no statistically significant association between the quartiles of the PRS and age at onset of PC (χ2 = 3.15; p = 0.369), PSA at diagnosis (χ2 = 3.58; p = 0.311), Gleason score (χ2 = 5.37; p = 0.147) or disease stage (χ2 = 1.41; P = 0.703; Supplementary Table 1).