The association between decreased HNF1B expression and malignant potential of ccRCC was also studied by Buchner et al., who examined the expression of HNF1B in ccRCC metastases on an mRNA level and found that the downregulation of HNF1B in ccRCC was associated with tumour progression and poor prognosis, suggesting that HNF1B might be a useful prognostic factor when stratifying patients with metastatic ccRCC into prognostic groups21. This evidence concerns the gene HNF1B and neoplasm.