CB13 up-regulates ER stress markers (e.g. p-PERK, p-eIF2α, ATF4, cleaved caspase-3, and CHOP), and TG, an ER stress inducer, has a synergic effect on ER stress in CB13-treated NSCLC cells. The gene discussed is DDIT3; the disease is non-small cell lung carcinoma.