MTR and infection: In particular, we were interested in (i) unraveling the mechanistic basis of methionine synthase essentiality in A. fumigatus, which is needed to fully explore the potential of this enzyme as a drug target and to be able to anticipate drug resistance mechanisms, and (ii) developing in vivo models of infection to mimic treatment against the target in an established infection and using them to validate methionine synthase as an antifungal drug target.