In the phase 2b PATHWAY study (ClinicalTrials.gov identifier: NCT02054130), tezepelumab significantly reduced asthma exacerbations over 52 weeks by up to 71% compared with placebo in patients with severe, uncontrolled asthma, irrespective of baseline levels of inflammatory biomarkers (e.g. blood eosinophil count, FeNO and IgE), and improved lung function, asthma control and patient HRQoL [28]. Here, IGHE is linked to asthma.