INS and type 2 diabetes mellitus: These results are in line with post-hoc analyses of four major trials in type 2 diabetes; The Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial [4], the Veterans Affairs Diabetes Trial (VADT) [5], The Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients with Type 2 Diabetes at High Risk of Cardiovascular Events (DEVOTE), and the Action to Control Cardiovascular Disease in Diabetes (ACCORD) trial [6, 7].