TPX2 and breast cancer: As expected, within the best ranking k-mers, iMOKA found overlaps with genes that have been extensively linked to breast cancer subtypes and are already used in the clinic such as estrogen receptor 1 (ESR1) [22], Forkhead Box A1 (FOXA1) [23], Forkhead Box C1 (FOXC1) [24], xenopus kinesin-like protein 2 (TPX2) [25], and Melanophilin (MLPH) [26].