In fact, it has been demonstrated that immunoneutralization of TRAIL is associated with rescue from death of human neuronal cells challenged in vitro with Aβ [13], and that blockade of the DR5 TRAIL-death receptor signaling with specific antibodies completely abrogates Aβ-induced neurotoxicity in both human neuronal cell lines and primary cortical neurons [133], suggesting a direct, Aβ-additive neurotoxic effect of TRAIL in the AD brain. This evidence concerns the gene TNFSF10 and Alzheimer disease.