Moreover, such TRAIL-related restrain of peripheral and CNS inflammatory/immune response in murine model of AD occurs along with decreased both microglial TNFα production, along with reduced accumulation of both Aβ and p-Tau protein in the hippocampus of 3xTg-AD mice treated with an anti-TRAIL antibody [18]. This evidence concerns the gene TNFSF10 and Alzheimer disease.