TRAIL, specifically expressed in the human AD brain [130], is abundantly released by human neural cells challenged with Aβ in vitro [13] and activated glia [131], and is also associated with reduced expression of the Na+-Ca2+ exchanger neuroprotective isoform NCX3, with a subsequent reduction of the energetic supply to neurons, in such manner providing redundant contribution to its potent proapoptotic effect in course of neurodegenerative process [132]. The gene discussed is TNFSF10; the disease is Alzheimer disease.