In the phase 2b PATHWAY study, treatment with tezepelumab significantly reduced the annualized asthma exacerbation rate (AAER), irrespective of baseline inflammation status, and improved lung function, asthma control and HRQoL in patients with severe, uncontrolled asthma [14], demonstrating that blocking TSLP can be an effective therapeutic approach in this patient population. This evidence concerns the gene TSLP and asthma.