Introduction of histamine (H2)-receptor antagonists, such as famotidine, cimetidine, and nizatidine, and proton pump inhibitors (PPIs), such as omeprazole, lansoprazole, pantoprazole, esomeprazole, and rabeprazole, for management of peptic ulceration has revolutionized the treatment options for peptic ulcer [8]. This evidence concerns the gene ATP12A and peptic ulcer disease.