Additionally, underexpression of TNNI3, TNNT1, and PITX2 might involve four independent pathways of cardiac muscle contraction, adrenergic signaling in cardiomyocytes, hypertrophic cardiomyopathy, and dilated cardiomyopathy, which are also incidentally associated through some somatic mutation and proto-oncogenic activities in LUAD. Here, PITX2 is linked to dilated cardiomyopathy.