We identified 12 important pathways that might have an essential role in the incidence and development of LUAD: pathways in cancer, ubiquitin-mediated proteolysis, protein processing in the endoplasmic reticulum, necroptosis, hypertrophic cardiomyopathy, cardiac muscle contraction, focal adhesion, the PI3K–Akt and Ras signaling pathways, the neurotrophin and mTOR signaling pathways, and the MAPK signaling pathway. Here, AKT1 is linked to cancer.