PTGs of modules were enriched in many signaling pathways, including necroptosis, protein processing in the endoplasmic reticulum, ubiquitin-mediated proteolysis, Parkinson’s disease, pathways in cancer, the MAPK signaling pathway, the mTOR signaling pathway, the Ras signaling pathway, the PI3K−Akt signaling pathway, Epstein−Barr virus infection, cardiac muscle contraction, adrenergic signaling in cardiomyocytes, hypertrophic cardiomyopathy, dilated cardiomyopathy, and the neurotrophin signaling pathway. The gene discussed is BDNF; the disease is dilated cardiomyopathy.