KEGG pathways have demonstrated that nicotine addiction, neomycin, kanamycin and gentamicin biosynthesis, complement and coagulation cascades, ECM-receptor interaction, and PI3K–Akt signaling pathways are enriched pathway terms regulating miR-1245 overlapping target genes in LUAD (Figure 2D). Here, AKT1 is linked to nicotine dependence.