Since cAMP-dependent cascades are directly involved in the regulation of steroidogenesis in Leydig cells, controlling the gene expression and activity of StAR and steroidogenic enzymes [6,7,9,10,11,12], the weakening of the AC response to hCG shown by us indicates an important contribution of disturbances in the gonadotropin-regulated AC signaling system into a decrease in hCG-stimulated steroidogenesis in T1DM and aging. Here, STAR is linked to type 1 diabetes mellitus.