There have been certain major findings in the mechanisms by which lncRNA cooperates with other proteins: (1) lncRNA interacts with TFs to transcriptionally regulate target gene expression in cancer [14], (2) lncRNA binds to DNMTs such as, DNMT1, DNMT3A, and DNMT3B, causing the alteration of gene methylation [15], (3) lncRNA can remodel chromatin states by forming a complex with PRC2 that is comprised of embryonic ectoderm development (EED), suz12 polycomb repressive complex 2 subunit (Suz12), and methyltransferase enhancer of zeste homolog 2 (EZH2) (Figure 1) [16]. Here, EZH2 is linked to cancer.