SP1 and breast cancer: In breast cancer, epigenetic regulators like DNMTs (1/3), HDAC, JARID1B (histone H3 lysine 4 demethylase) and sp1 (Sp1 Transcription Factor) cause both higher and lower expression of several miRNAs including miR-124.3, miR148a, miR-375, miR-152, members of miR-200, let-7 and miR-34 families [5,36,85,87,104,105,106,107,108,109].