Several reports have demonstrated that DNMT3a and DNMT3b are fre-quently overexpressed in cancers with poor prognosis, and targets of the miR-29 family, miR-101, miR-143, mir-148a and miR-152 have been reported in various forms of cancer [37,41,43,45,46,47,51,59,61,62,65,66]. The gene discussed is DNMT3B; the disease is cancer.