NOTCH1 and cancer: Indeed, our data indicate that hypoxic tumours also load EVs with proteins including stanniocalcin 1 (STC1) and transmembrane protein 59 (TMEM59/DCF1), which have been reported to induce stem-like traits in recipient cancer cells via activation of the NOTCH1-SOX2 signalling pathway and control of cellular differentiation, respectively [58,59,60,61].