TMEM59 and cancer: Several of these HSEPs have been reported in other contexts to play key roles in tumour progression by cancer cell proliferation (NRSN2, WISP2, SPRX1, LCK), metastasis (GOLM1, STC1, MGAT5B), and stemness (STC1, TMEM59), as well as promoting angiogenesis (ANGPTL4) and host immunosuppression (CD70).