Several of these HSEPs have been reported in other contexts to play key roles in tumour progression by cancer cell proliferation (NRSN2, WISP2, SPRX1, LCK), metastasis (GOLM1, STC1, MGAT5B), and stemness (STC1, TMEM59), as well as promoting angiogenesis (ANGPTL4) and host immunosuppression (CD70). This evidence concerns the gene CCN5 and cancer.