Several of these HSEPs have been reported in other contexts to play key roles in tumour progression by cancer cell proliferation (NRSN2, WISP2, SPRX1, LCK), metastasis (GOLM1, STC1, MGAT5B), and stemness (STC1, TMEM59), as well as promoting angiogenesis (ANGPTL4) and host immunosuppression (CD70). The gene discussed is STC1; the disease is cancer.