In order to appreciate a contribution of cell fusion to the formation of polynuclear tAMs under allergic asthma conditions, we also delineated the expression of several genes associated to cell-cell fusion, such as Gja1, encoding Connexin 43, P2x7 and Panx1. None of these genes increased in MHCII+ cells upon HDM compared to PBS controls (Figure 4F). Here, GJA1 is linked to allergic asthma.