NOS2 and central nervous system cancer: In rat C6 glioma cells, treatment with PEA-um (10 μM) significantly reduced iNOS and COX-2 expression following damage induced by LPS/IFN γ (Figure 4A,B), but the protective effects of PEA-um were enhanced in LPS/IFN γ-stimulated cells in which NAAA enzyme was muted (Figure 4A,B).