For the first time, in this study, we demonstrated that treatment with PEA-um, at the highest concentration of 10 μM, significantly reduced inflammation as showed by a decreased expression in iNOS and COX-2 protein levels, in glioma and in neuroblastoma cells, as well as in microglia and oligodendrocytes, compared to cells stimulated but not treated. The gene discussed is PTGS2; the disease is neuroblastoma.