Additionally, RT enhances activation of proliferating machinery involving the RAS and mitogen-activated protein kinase (MAPK) cascades; the invasion pathways, which involve matrix metalloproteins (MMPs), laminin 5, and filamin A; transforming growth factor beta (TGFβ) signaling, which is involved in tumor progression, resistance, and metastasis [2,7,37]. Here, TGFB1 is linked to neoplasm.