The promotion of cancer cell proliferation by over activation of the Nrf2/ARE pathway is associated with the stimulation of several metabolic pathways, such as glutathione synthesis [180,182], fatty acid and lipid biosynthesis [180,182,183,184,185], the pentose phosphate pathway, and the tricarboxylic acid cycle [186] (Figure 2). Here, NFE2L2 is linked to cancer.