NFE2L2 and type 2 diabetes mellitus: In another study, Dong and colleagues (2020) showed that baicalein upregulates Nrf2 nuclear translocation in high glucose-induced human liver L-02 (synonym: HL-7702) cells, and the liver cells of T2DM Kunming mice, and reduces oxidative stress in both the L-02 and the liver cells of T2DM Kunming mice, in addition to the reduction of L-02 cell apoptosis [120].