TGFB1 and pemphigus foliaceus: PF development is associated with granulomatous inflammation and leukocyte infiltration, mainly neutrophils, eosinophils, mononuclear cells (subpopulations of both macrophages and lymphocytes), myeloid derived-suppressor cells (MDSCs), and fibrocytes (all cells enumerated by flow cytometry), followed by an increase of pro-inflammatory and pro-fibrotic cytokine production including tumor necrosis factor alfa (TNF-α), transforming growth factor-beta (TGF-β), interleukin (IL)-1, IL-6, IL-13, and IL-17 [10,24].