MAPT and supranuclear palsy, progressive, 1: Furthermore, in PSP, tau imaging with a 2-(1-{6-[(2-18F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile 18F-FDDNP probe allows the detection of tau aggregates in subcortical and cortical areas with a typical pattern of PSP and may be a valuable diagnostic tool for all PSP phenotypes or a prognostic biomarker [86].