SNCA and multiple system atrophy: The alpha-synucleinopathies (SNCApathies) are a group of several neurodegenerative diseases that are characterized by the pathological accumulation of alpha-synuclein aggregates in neurons and cells of the Central nervous system (CNS), including dementia with Lewy bodies (DLB), Parkinson’s disease (PD), or multiple system atrophy (MSA).