The most common MYD88 mutation consisted of a single nucleotide leucine (CTC) to proline (CCG) exchange at position 265 (L265P) in the Toll/interleukin (IL)-1 (TIR) receptor domain of MYD88, and it was detectable in 29% of non-GCB DLBCL biopsies [16]. This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.