The most recent World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues has divided DLBCLs into three main subgroups based on morphological and molecular specificities: DLBCL NOS (not otherwise specified), high-grade B-cell lymphomas with or without MYC and BCL2 and/or BCL6 translocations, and other lymphomas of large B cells [3]. This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.