The most recent World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues has divided DLBCLs into three main subgroups based on morphological and molecular specificities: DLBCL NOS (not otherwise specified), high-grade B-cell lymphomas with or without MYC and BCL2 and/or BCL6 translocations, and other lymphomas of large B cells [3]. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.