CD4 and neuroblastoma: Examining a series of 84 NB tumors by IHC for the presence of CD3+, CD4+ and CD8+ T cells and defining an immunoscore, Mina et al. found that infiltrating T cells have a good prognostic value independent of the current indicators used for NB staging including MYCN-A, but they reported the presence of a defined subset of infiltrating T cells (high CD3+ or low CD3+ and high CD4+/CD8+ ratio) associated with a more favorable outcome in both MYCN-A and MYCN-NA tumors [37].