MYCN and neuroblastoma: Proteomic analysis performed on exosomes from two NB cell lines with different MYCN amplification status reflects their role in the aggressiveness of NB, as exosomes from MYCN-A SK-N-BE(2) cells are enriched in proteins involved in signal transduction, cell communication and transport, while exosomes from MYCN-NA SH-SY5Y are enriched in protein metabolism, cell growth, and maintenance and regulation of nucleic acid metabolism, suggesting that SK-N-BE2 cell-derived exosomes are enriched with proteins that could regulate various signaling pathways in the recipient cells [85].