SMPD3 and central nervous system cancer: Interestingly, amongst all of the highly expressed genes in this pathway, SMPD3 overexpression was associated with improved survival in both IDHmut and IDHWT; however, it was more significant in IDH1mut lower grade gliomas (p value of 1.2 × 10−8 for IDHmut compared with 1.7 × 10−3 for IDHWT) (Figure 3d).