KLK3 and posterior cortical atrophy: In the multicentric study, PRIM (PHI to refIne MRI), conducted by Lois Kim et al. 2020 on a cohort of 545 men, PHI proved better detection of significant (GG ≥ 2) PCa than PSA and PSAD with an AUC of 0.82 vs. 0.70, 0.79.