In the same clinical trial, but at rebiopsy (the first biopsy was negative), the AUC for 4Kscore vs. base model (PSA, age, DRE) was 0.681 vs. 0.584 for detection of any PCa, and 0.873 vs. 0.764 in detecting high-grade cancer. This evidence concerns the gene KLK3 and posterior cortical atrophy.