In the same vein and with similar acid–base effects on cell homeostatic mechanisms to other PTs, MCTs induce: (a) further alkalization of the pHi of cancer cells; (b) worsening of TME acidosis by removing lactic acid from the intracellular space [55], and (c) cell proliferation, migration, invasion, angiogenesis and survival [86]. Here, PTS is linked to cancer.